منابع مشابه
Gene Delivery Systems
Gene therapy has undergone a remarkable development in the last 20 years. Particularly important advances have been made in the improvement of gene transfer and expression technology, with current efforts focusing on the design of safer and long-term gene expression vectors as well as systems possessing cell-type specificity for transgene delivery and regulat‐ ability of its expression by small...
متن کاملAdvances in Gene Delivery Systems
1Department of Biotechnology, School of Life Sciences, Central University of Rajasthan, Bandarsindri, N.H. 8, Tehsil Kishangarh, District Ajmer, Rajasthan 305817, India 2Genomics and Nanotoxicology, Laboratory Mechanistic Studies Division, Health Canada, Ottawa, ON, Canada K1A 0K9 3Department of Electro and Biophysics, Plasma Bioscience Research Centre, Kwangwoon University, Wolgye-Dong, Nowon-...
متن کاملTargeting of Synthetic Gene Delivery Systems
Safe, efficient, and specific delivery of therapeutic genes remains an important bottleneck for the development of gene therapy. Synthetic, nonviral systems have a unique pharmaceutical profile with potential advantages for certain applications. Targeting of the synthetic vector improves the specificity of gene medicines through a modulation of the carriers' biodistribution, thus creating a dos...
متن کاملNon-Viral Delivery Systems in Gene Therapy
Recent advances in molecular biology combined with the culmination of the Human Ge‐ nome Project [1] have provided a genetic understanding of cellular processes and disease pathogenesis; numerous genes involved in disease and cellular processes have been identi‐ fied as targets for therapeutic approaches. In addition, the development of high-throughput screening techniques (e.g., cDNA microarra...
متن کاملPolydnaviruses as Symbionts and Gene Delivery Systems
Textbooks define viruses as infectious agents with nucleic acid genomes (RNA or DNA), which replicate inside living host cells to produce particles (virions) that can transfer the genome to other cells [1,2]. The Polydnaviridae was recognized as a family of viruses in 1995, and is currently divided into two genera named the Bracovirus and Ichnovirus [3]. Polydnavirus (PDV) virions consist of en...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.481